Figure 4: Pan-cancer network of miRNA-target interactions.
From: Analysis of microRNA-target interactions across diverse cancer types
(a) Pan-cancer network defined by intersection of miRNA-mRNA pairs with strong negative REC scores and strong evidence for conservation-based target interaction. (b) Inferred pan-cancer network comprising 143 putative target interactions between 40 evolutionarily conserved miRNAs and 72 target mRNAs. Edge width represents strength of the REC score for a given miRNA-mRNA pair, and miRNAs are color coded by seed family relationships (singletons in white). (c) Genetic and epigenetic alterations regulating miRNAs. For the 40 miRNAs in the pan-cancer network and all other miRNAs also expressed across all the studied cancer types (n = 180), we estimated the extent (third highest R2 measured in the ten cancer types) to which changes in copy number (left) or promoter DNA methylation (right) at the miRNA locus could explain the variation in miRNA expression.
