Supplementary Figure 2: Structure-based sequence alignments of Not1c, Not2 and Not5c.
From: Structure and RNA-binding properties of the Not1–Not2–Not5 module of the yeast Ccr4–Not complex
The sequence alignments include the polypeptides of S. cerevisiae (Sc) Not1, Not2 and Not5 we crystallized in a complex and their orthologues from H. sapiens (Hs) and D. melanogaster (Dm). Not5Sc is a homologue of Not3. Secondary structure elements are shown above the sequences and colored in yellow for Not1 (a), magenta for Not2 (b) and green for Not5 (c). Straight lines refer to extended regions and dotted lines refer to disordered regions in the structure of the S. cerevisiae complex. Sequence conservation is highlighted in shades of gray.
