Supplementary Figure 2: Receptor comparative model construction.
From: Energetic analysis of the rhodopsin–G-protein complex links the α5 helix to GDP release
(a) Alignment of B2- adrenergic receptor with metarhodopsin as performed by MUSTANG2. Amino acids groups for the energetic analysis are outlined in bold and named according to sequence location. Strands are highlighted in blue. Helices are highlighted in red; dark red is used to separate consecutive helices. Residues with green text were rebuilt using the Rosetta loop building protocol. (b) Superimposition of the receptor comparative model (orange/green) overlayed on the template structure B2-adrenergic receptor (grey). Residues rebuilt using the Rosetta loop building protocol are colored in green.
