Supplementary Figure 7: Nucleosome solubility and turnover as a function of Pol II kinetics.
From: Transcription-generated torsional stress destabilizes nucleosomes
(a) Heat maps of 80 mM salt soluble nucleosomes are displayed for Topo I- (left) and Topo II-inhibited (right) samples as performed in main Fig. 5c but with genes arranged by change in stalled Pol II. Nucleosomes of genes that increase in stalled Pol Il after topo inhibition have increased low-salt solubility. (b) Heat maps of CATCH-IT are displayed for Topo I- (left) and Topo II-inhibited (right) samples as performed in Fig. 6b but with genes arranged by change in stalled Pol II. Genes that increase and decrease in stalled Pol II after topo inhibition results in increased nucleosome turnover. Ctl: control.
