Supplementary Figure 1: Topoisomerase alignment.
From: Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1
Human TopIIIa is the upper sequence; 2. Saccharomyces cerevisiae Top3; 3. Escherichia coli Top3; 4. Escherichia coli Top1A; 5. Thermatoga maritima Top1A. The alignment has been made with T-COFFEE (http://tcoffee.vital-it.ch) and edited to show similarity percentage with a threshold set up at 3. Percentage of similarity is coloured as a gray scale, the four different levels being (from white to black): White is less than 60%, light gray is between 60 to 80%, dark gray is 80 to 99% and black is 100%.
