Supplementary Figure 5: Differential scanning fluorimetry analysis of single-chain TYK2–IFNAR1 wild-type and mutant complexes
From: Structural basis of recognition of interferon-α receptor by tyrosine kinase 2
Curves are plotted and overlaid for each individual experiment, with apparent melting temperature (Tm), standard deviation (SD), P-value (calculated by unpaired, two-tailed students t-test) comparing the mutants against wild type, and number of samples (n) are printed below each graph. At the bottom, representative fitted curves are plotted and overlaid for each of the proteins to illustrate the experimental curve differences between the wild type and IFNAR1 mutants.
