Supplementary Figure 2: Structural analysis and crystal packing of the TYK2–IFNAR1 complex
From: Structural basis of recognition of interferon-α receptor by tyrosine kinase 2
(a) Stereo view cartoon diagram of the TYK2 FERM–SH2 in complex with IFNAR1. TYK2 is colored as a rainbow, with blue starting at the N-terminus to red at the C-terminus. IFNAR1 is colored yellow. (b) Stereo view of electron density (2Fobs-Fcalc contoured at 1σ) around the SH2 domain and IFNAR1 peptide. The backbone is shown as a ribbon with sidechains shown as stick models, with TYK2 colored as in (a). (c) Analysis of crystal packing and contacts near the IFNAR1 peptide. Front view and side view of the TYK2–IFNAR1 complex showing nearest neighbors to IFNAR1 in the crystal lattice. IFNAR1 does not participate in any crystal contacts, indicating the peptide is bound in the native conformation.
