Supplementary Figure 5: The ‘substrate-occluded’ crystal structure overestimates the closing of TMs 1a and 2 on the intracellular side. | Nature Structural & Molecular Biology

Supplementary Figure 5: The ‘substrate-occluded’ crystal structure overestimates the closing of TMs 1a and 2 on the intracellular side.

From: Conformational dynamics of ligand-dependent alternating access in LeuT

Supplementary Figure 5

Comparison between experimental and MMM-predicted distances shows systematic deviations in the distributions of TMs 1a and 2. In contrast to the extracellular side, here the average distances are larger than those predicted by the occluded structure.

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