Supplementary Figure 3: Conserved interactions centered on Pan3.
From: The structure of the Pan2–Pan3 core complex reveals cross-talk between deadenylase and pseudokinase
(a) Superposition of the atomic models of the individual protomers of a Pan3ΔN dimer from the yeast Pan2ΔN–Pan3ΔN structure (with the two chains in yellow and orange) with those of the N. crassa Pan3CR dimer28 (in gray, left panel) and of the D. melanogaster (in gray, right pane) in isolation. Note that helix αN (from the extension upstream of the pseudokinase domain) is not present in the D. melanogaster structure. Abbreviation: CR (C-terminal region, residues 275–679). (b) The surfaces of the knob domains are shown, colored according to sequence conservation from light (less conserved) to dark (conserved), with the Pan2 linker in ribbon representation. Indicated are the positions of the residues of yeast Pan3 corresponding to mutants previously described28. Abbreviation: N-term. (N-terminus).
