Supplementary Figure 8: Model of regulation of expanded RNAs.
From: Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans
(A) Model for regulation of expanded RNA toxicity by the NMD pathway: NMD targets expanded CUG repeat transcripts for degradation reducing the levels of toxic RNAs present in the cells. A decrease in NMD function results in accumulation of toxic transcripts with increase in nuclear RNA foci and increase in toxicity with loss of motility. (B) Model for regulation of expanded RNA foci accumulation by the modulators of RNA toxicity identified: different pathways regulate expanded CUG repeat toxicity; an increase in foci causes a decrease in locomotion however, a decrease in foci doesn’t necessarily correlate with a decrease in muscle toxicity.
