Supplementary Figure 3: Box plots and chromosome viewers comparing WT and TRIM28-KD mESCs.
From: TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release
(a) and (b) Change in Gene Body Pol II of TRIM28-bound and –unbound genes. Change in normalized, input-adjusted total PolII ChIP-seq gene body reads per kilobase on TRIM28 KD as a function of TRIM28 binding. Values are plotted for genes intersecting (a) and not intersecting CpG islands (b) (p-values derived from Wilcoxon Rank Sum test). (c) UCSC Browser views of paused genes in replicates. Chromosome views of EGR1 (c), JUN (d), and ERK1 (e) with normalized and input-adjusted Total PolII ChIP-seq read counts in WT and TRIM28 KD mES cells.
