Supplementary Figure 4: SUMOylation occurs on phylogenetically highly conserved proteins.
From: Uncovering global SUMOylation signaling networks in a site-specific manner
(a) Phylogenetic conservation analysis (within orthologues) of SUMOylation, as compared to other major PTMs ubiquitylation, acetylation, methylation and phosphorylation, as well as all human proteins (total). The conservation line descends by average percentage of conservation from human to 62 Ensembl-annotated eukaryotic organisms. The analysis was performed within orthologues, and only genes that have an orthologue were considered on a per-organism basis. P values for significance of difference between all datasets are indicated, and were determined by two-tailed paired Student’s t test.
(b) Phylogenetic conservation analysis outside of orthologues. Synonymous to (a), with the exception that genes lacking an orthologue were considered to be 0% conserved on a per-organism basis. P values for significance of difference between all datasets are indicated, and were determined by two-tailed paired Student’s t test.
