Supplementary Figure 2: Sequence alignment of the Vps10p domains.
From: Structural basis for amyloidogenic peptide recognition by sorLA
Amino acid sequences are from human sorLA (SORLA_hu, NP_003096.1), human sortilin (sort_hu, CCA66904), mouse SorCS1 (sorCS1_mo, Q9JLC4), and yeast Vps10p (Vps10p_sp, O42930). Secondary structure elements are denoted by straight (strands) or wavy (helices) lines below each sequence. Strand designation is shown above the alignment with the same color code as in Fig. 3. The L1 and L2 segments are highlighted in salmon and cyan, respectively. Cysteines are shown with a grey background with lines connecting the disulfide-bonded pair. The Gly511 mutated in a familial AD patient is marked by a red box. Propeptide cleavage sites are indicated by “//”.
