Supplementary Figure 5: DUB activity of full-length hCYLD.
From: Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity
The full-length hCYLD was overexpressed in HEK293T cells.
(a) Linkage specificity of full-length hCYLD. All possible linkage types of Ub2 were cleaved by the full-length hCYLD.
(b) Cleavage of Met1 and Lys63 chains by full-length wild-type or mutant hCYLD
