Supplementary Figure 2: Mapping of the positions showing modification by MTS compounds.
From: A specialized molecular motion opens the Hv1 voltage-gated proton channel
Mapping of the positions showing modification by MTS compounds onto the mHv1cc crystal structure1, viewed from the interior of the VSD. S2 and S3 segments were removed for clarity reasons. Positions of the α-carbons of S1 residues showing state-dependent and state-independent MTS modification are depicted as green and orange spheres, respectively. Except for V151 and K173, residues showing MTS modification are located on the same helix face as D1 (D160, pink sphere), and are thus likely to face the channel pore. S4 arginine side chains are shown as sticks.
1. Takeshita, K. et al. X-ray crystal structure of voltage-gated proton channel. Nat Struct Mol Biol (2014).
