Supplementary Figure 6: Representative poses from top-scoring RosettaDock clusters in addition to the top pose shown in Figure 4d. | Nature Structural & Molecular Biology

Supplementary Figure 6: Representative poses from top-scoring RosettaDock clusters in addition to the top pose shown in Figure 4d.

From: Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

Supplementary Figure 6

NCAM FN1 domain colored according to energy plot on Figure 4c. Superposed NCAM Ig5 domain (not used in docking) colored grey and distances between modified glycans Asn449 and Asn478 to active site Lys297 shown (diamond; only labeled in top left panel). The ST8SiaIV PBR is colored blue and the PSTD cyan. Residues implicated in the interaction are shown as spheres (NCAM FN1 acidic patch marked with a circle, ST8SiaIV PBR Arg93 marked with star, PBR Arg82 with a diamond; top left panel only) as is Asn74 (ST8SiaIV numbering), the major site of autopolysialylation (square; only labeled in top left panel).

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