Supplementary Figure 4: Model of the TNT–NAD+ complex.
From: The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD
(a) Docking of NAD+ inside TNT putative active site crevice performed using AutoDock Vina. NAD+ is shown in sticks and TNT as a green "Connolly" surface. (b) Ribbon representation of the docking model in panel (a) with magnified view of TNT residues in the palm-domain predicted to be important in the NAD+ binding and hydrolysis.
