Supplementary Figure 2: Topology of the Rabin8C domain.
From: Structure of Rab11–FIP3–Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11
Searches using the DALI server (Holm, L & Rosenström et al., Nucleic Acids Research. 38, W545–9, 2010) with the Rabin8C structure did not reveal any previously determined structure of the same fold. The diagram on the left shows the topology of one Rabin8C monomer in orange with the domain-swapped beta-strands of the neighboring subunit in the homo-dimer shown in yellow. The topology diagram was generated using Pro-origami (Stivala, A. et al., Bioinformatics. 27, 3315–3316, 2011). The right panel shows the Rabin8C dimer structure. The two subunits are interlinked via the domain-swapped beta-strands to resemble a single pair of crab claws and we thus designate the Rabin8C fold the Crab-fold.
