Supplementary Figure 1: Sequence alignment.
From: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family
Sequence alignment of SLC26Dg (GI:499845065), the E. coli transporter DauA (GI:115512548) and human Prestin (SLC26A5, GI:30348882). The Alignment was improved based on the SLC26Dg structure and the structures of the STAS domains of Prestin and DauA. Secondary structure elements of SLC26Dg are shown below. The two halves of the transmembrane domain are colored in green and beige respectively. The STAS domain is colored in red. The numbering corresponds to SLC26Dg. Selected residues in the aqueous cavity in proximity to the potential substrate binding site are indicated as blue or beige dots, the start of the STAS domain as red dot.
