Supplementary Figure 5: Comparison of HflX with translation factors on the 50S subunit. | Nature Structural & Molecular Biology

Supplementary Figure 5: Comparison of HflX with translation factors on the 50S subunit.

From: HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions

Supplementary Figure 5

(a) A thumbnail of the 50S–HflX–GMPPNP structure in the top left corner and superimposition of HflX with canonical translation factors on the 50S subunit. HflX is colored magenta and other translation factors are colored blue. IF2 (PDB id:1ZO1)2, EF-Tu (PDB id: 2XQD)3, EF-G (PDB id: 2WRI)4, LepA (PDB id: 4W2E)5, RF1 (PDB id: 3D5A)6, RF2 (PDB id: 3F1G)7, RF3 (PDB id: 3SFS)8, RRF (PDB id: 4GD1)9, and YaeJ (PDB id: 4DH9)10. (b) Relative orientation of the GTPase domain (yellow) of HflX and known translation factors to the SRL of the 23S rRNA. For clarification, only the GTPase domains of translation factors are shown. PDB codes of the GTPases shown are same as in a.

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