Supplementary Figure 4: Crystal structures of EGFR in complex with peptides.
From: EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src

(a) (b) Electron density of peptides in complex with EGFR L858R kinase domain. Fo-Fc difference omit maps (in which the peptides were omitted) for the optimal peptide (a) or the primed Shc1 peptide (b) contoured at 3σ. (c) Interactions between the EGFR L858R kinase domain and the optimal substrate peptide (DEEDYpYEIP). Hydrogen bonds are indicated with dashed lines.