Supplementary Figure 4: Reduction in Tip60–p400 binding to target genes upon Rnaseh1 overexpression.
From: R loops regulate promoter-proximal chromatin architecture and cellular differentiation
a-b, Browser tracks of Tip60 or p400 ChIP-seq data at two Tip60–p400 target genes, Rps9 (a) and Rpl8 (b) in control cells or Rnaseh1 overexpressing cells. Gene expression is shown as RNA-seq tracks for each gene. c, Two genes are shown with high (Cdc6) or low (Wipf2) expression levels to illustrate that some lowly expressed genes with R-loops exhibit Rnaseh1-sensitive Tip60–p400 binding, and some highly expressed genes without detectable R-loops are not highly bound by Tip60–p400.
