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A new communication hub in the RNA world

Nature Structural & Molecular Biology volume 23, pages 189–190 (2016)Cite this article

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During assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), the RNA-binding protein (RBP) Gemin5 recognizes the snRNP code and interacts with the large Gemin2–SMN complex. So et al. now find that Gemin2 also interacts with U1-70K, thereby conferring a preferential advantage on U1 snRNP assembly, and they extrapolate that SMN–Gemin2 serves a general ribonucleoprotein-exchange function.

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Figure 1: The SMN complex serves as a hub facilitating exchange of RNA cargos from a variety of RBP donors and acceptors and thus plays a central role in RNA metabolism.

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Authors and Affiliations

  1. Megan Mayerle and Christine Guthrie are at the Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA,

    Megan Mayerle & Christine Guthrie

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  1. Megan Mayerle
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  2. Christine Guthrie
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Correspondence to Christine Guthrie.

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Mayerle, M., Guthrie, C. A new communication hub in the RNA world. Nat Struct Mol Biol 23, 189–190 (2016). https://doi.org/10.1038/nsmb.3178

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