Supplementary Figure 3: Excess Axin WT suppresses Axin L106R–induced β-catenin–mediated transcription.
From: Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network
Wnt luciferase reporter activity in HEK293T cells co-expressing Axin-L106R with increasing doses of Axin-wt protein. Axin-L106R induces basal β-catenin mediated transcription. Co-expression of increasing amounts of Axin-wt protein levels suppresses Axin-L106R induced β-catenin mediated transcription. Graph shows average (bars) and range (diamonds) of luc activity in duplicate cell cultures.
