Supplementary Figure 5: STRING v10 analysis of lost and gained binders of Axin-variant interactomes.
From: Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network
(a) Interactome (grey dots) of Axin-wt (red dot) is shown. Shown interactors displayed a confidence score of >0.900 and interaction with at least one other partner in the network. Binding partners are clustered (grey circles) based on previously described protein-protein interactions and on shared activity in the regulation of cellular processes as revealed by GOTERM analysis. Loss of binding (blue dots) is indicated for (b) Axin-ΔRGS, (c) Axin-L106R and (d) Axin-L106R F119R. (e) Gained interactions (green dots) of Axin-L106R are shown, based on comparison with the Axin-wt interactome in (a). Partners that were trapped by Axin-L106R and set free by Axin-L106R F119R are indicated (yellow dots).
