Supplementary Figure 7: Effect of R55E mutation on the inhibition potency of INCA.
From: Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism
This charge-reversal mutation at the type Ia interface greatly reduced INCA's inhibition potency on nucleated caspase-1CARD polymerization. Notably, the Ki is increased to ~1.7 μM.
