Supplementary Figure 1: Cryo-EM structure determination of the caspase-1CARD filament.
From: Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism
(a) Enlarged experimental and simulated power spectra showing the position of the meridional layer line. (b-c) A magnified view of the cryo-EM density for helix 1 and helix 4. (d-e) Gold standard and model versus map Fourier shell correlation plots showing the estimated resolution at 4.8 Å. (f) Summary of MolProbity validation report for the caspase-1CARD filament model. (g) Superposition of the caspase-1CARD structure in the filament with the NMR structure of ICEBERG and a homology model of INCA based on the ICEBERG structure.
