Supplementary Figure 1: Characterization of RB011.
From: Structural basis for specific inhibition of Autotaxin by a DNA aptamer
a, b, RB011 binding to ATX measured by SPR. Sensorgrams of different concentrations of RB011 (50, 25, 12.5, 6.25 and 3.12 nM from upper to lower sensorgrams) binding to human ATX (a) and mouse ATX (b). c, Sensorgrams of RB011 binding to mouse ATX (ENPP2) and ENPP1. d, Plasma pharmacokinetic profiles of the PEGylated RB011. The PEGylated RB011 was administered intravenously, subcutaneously, or intraperitoneally to C57BL/6J mice at 10 mg/kg. Data are mean ± S.E.M. (n = 3, number of mice). e, Pharmacokinetic parameters.
