Supplementary Figure 3: LINP1 RNA associates with Ku80 and DNA-PKcs. | Nature Structural & Molecular Biology

Supplementary Figure 3: LINP1 RNA associates with Ku80 and DNA-PKcs.

From: Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

Supplementary Figure 3

(a) RNA pull-down assay in combination with MS analysis was used to identify binding proteins of LINP1. Left, mass spectroscopy identifies peptides mapped to Ku80 and DNA-PKcs, respectively. Right, peptide coverage of these two proteins; blue indicates the covered regions. (b) Deletion mapping of Ku80 and DNA-PKcs -binding domains in LINP1. Left panel: the schematic diagram of full-length and deleted fragments of LINP1. Right panel: quantitative data of the binding intensity between LINP1-Ku80 (left) or LINP1-DNA-PKcs (right).

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