Supplementary Figure 2: In vivo evaluation of AM-1488 in a mouse open field assay.
From: Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators
(a) AM-1488 had no significant effect on the total basic movements (5708 ± 482 cm, N=10), when compared to the vehicle treated group (5052 ± 131 cm, N=10; t18 = 1.3, p > 0.05) at 60 min post oral dosing in naïve mice. (b) AM-1488 had slight reduction on total rearing counts (354 ± 137), when compared to the vehicle treated group (498 ± 149; t18 = 2.2, p < 0.05). All values are mean ± s.e.m. except Cu values which are mean ± s.d..
