Supplementary Figure 5: Distribution of C. elegans origins relative to genes and promoters.
From: The gastrula transition reorganizes replication-origin selection in Caenorhabditis elegans
(a) Percentage of pre-gastrula (green) and post-gastrula-specific (orange) replication origins around non-coding TSSs (±3000 bp) in the chromosome arms (left panel) or centers (right panel). Mean random profiles are represented by a full line (± standard error in dashed lines) in a lighter color than the one used for the real data. (b) Box plots showing the percentage of pre-gastrula (green) and post-gastrula-specific (orange) origin summits found in all non-coding gene promoters (total promoters) as well as in non-coding gene promoters in chromosome centers, left and right arms. *, P<10-20 (according to the distribution function of the normal distribution); n.s., non-significant difference with random expectation (mean ± s.d.). (c) ChIP signals for histone H3K4me3 and RNA pol II around ±2 kb from the TSS of non-coding genes overlapped (left panel) or not (right panel) by post-gastrula-specific origins. The y-axis represents the average ChIP signal per 100 bp.
