Supplementary Figure 8: Comparison of the P1-binding pockets of C. elegans separase and CtSPD.
From: Cryo-EM structure of a metazoan separase–securin complex at near-atomic resolution
The P1-binding pockets of C. elegans separase and CtSPD were superimposed and shown with the corresponding C. elegans EM density. EM density for selected separase residues is shown in grey and Met126Sec density is coloured red. Whereas there is a good fit for the C. elegans structure, CtSPD fits poorly, especially Gly2082 and His2083, due to the narrower P1-binding pocket of CtSPD.
