Supplementary Figure 3: The α-solenoid domain of Ce separase forms a distorted TPR-like superhelix with 11 TPR motifs.
From: Cryo-EM structure of a metazoan separase–securin complex at near-atomic resolution
a, α-solenoid domain of Ce separase shown with its 25 α-helices represented as cylinders and colour-ramped from the N- to C-terminus blue to red. TPR motifs TPR1 and TPR11, and α-helices are labeled, as are the positions of insert-1 and insert-2. H2, H16 and H25 are not part of the TPR superhelix. b, An idealized TPR superhelix of eleven TPR motifs superimposed onto the Ce separase α-solenoid TPR-like domain. The Ce separase α-solenoid domain is considerably compressed compared to the idealized TPR superhelix of eleven TPR motifs. H2, H16 and H25 of the Ce separase α-solenoid do not share counterparts in the eleven-motif TPR superhelix.
