Supplementary Figure 1: Chemical structure of LPS and LPS biogenesis in Gram-negative bacteria. | Nature Structural & Molecular Biology

Supplementary Figure 1: Chemical structure of LPS and LPS biogenesis in Gram-negative bacteria.

From: Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

Supplementary Figure 1

a. Chemical structure of LPS. LPS molecule consists of Lipid A, core oligosaccharide and O-antigen. The polar part of Lipid A is negatively-changed due to the presence of two phosphate groups. b. Ra-LPS molecule is approximately 32Å in height and 28 Å×12 Å in the other two dimensions. The dimensions of an Ra-LPS is based on the crystal structure of TLR4/MD-2/Ra-LPS complex (PDB ID: 3FXI). c. LPS biogenesis in Gram-negative bacteria. After flipped to the IM outer leaflet by MsbA, LPS is extracted from IM, transported cross the periplasm and finally inserted in the OM by the LptABCDEFG transenvelope complex. LptB2FG is a quaternary ABC transporter.

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