Supplementary Figure 6: Structure of MESFPGWNLV(hR)IGLLR bound to PCSK9ΔP’ explains antagonism.
From: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists
Hydrophobic contacts involving side chains from new residues M1 and F4 and residues W7, V10 and hR11 help determine the conformation of the N-terminal extension. Carbon (and sulfur) atoms from these side chains are shown with dotted surfaces.
