Supplementary Figure 2: Surface plasmon resonance measurements of PCSK9 variants binding to immobilized LDLR-Fc.
From: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists
Shown are sensorgrams (different color for each concentration) and fitted curves (black) of (a) PCSK9 (KD 103 ± 3.4 nM), (b) PCSK9-AAA (KD 138 ± 1.3 nM) and (c) PCSK9ΔP' (KD 541 ± 8.2 nM). The KD values, calculated from the determined kon and koff values, were the average ± s.d. of three independent experiments.
