Supplementary Figure 1: Amino-acid sequence alignment of the USP domains of zUSP30 and hUSP21.
From: Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30
The Ubdist- and Ubprox-interacting residues of zUSP30 are indicated by cyan and pink squares, respectively. Residues interacting with both Ub moieties are indicated by blue squares. The catalytic triad and the Zn2+-coordinating residues are indicated by yellow and green stars, respectively. The residue number and secondary structure of zUSP30 are shown above the alignment. Secondary structure elements of the thumb, palm and fingers subdomains and insertions of zUSP30 are colored green, gray, orange and yellow, respectively. The disordered regions of zUSP30 and hUSP21 (PDBID 3I3T)30 are highlighted in purple.
