Supplementary Figure 6: Comparison of mutation patterns between the nuclear core and periphery in benign human cell types.

A) Data for somatic mutations detected in benign fibroblasts were obtained from Abyzov et al. Genome Res. 27, 512-523, 2017. Mutations were called based on human induced pluripotent stem cell (hiPSC) lines generated from reprogrammed skin fibroblast cells from families of donors. The SNV data was processes and analyzed in a manner similar to that described in Figure 2 and 3. B) Adjusted mutation rate (AMR) for cLAD was higher than that for iLADs, showing a trend consistent with that observed in the cancer genomes (Figure 2). But the the number of somatic mutations in each category per donor was small, and the difference was not statistically significant (Mann Whitney U test, p-value >0.05) or in the multivariate analysis similar to that presented in Figure 3. Whiskers in the boxplot indicate upper and lower quartiles.