Supplementary Figure 2: Chromosome-level differences in patterns of genomic alterations.
From: Nuclear topology modulates the mutational landscapes of cancer genomes
(A) There was no significant difference in the chromosome average copy number log2 ratios between chr18 and chr19 in the LUSC cohort (p-value >0.1; Mann Whitney test), indicating that lower AMR in chr19 was not due to recurrent copy number loss of segments of this chromosome. (B) Chromosome-wise AMR and copy number log2 ratios for cLAD and iLADs in the LUSC cohort, shown after grouping according to chromosomes show that difference in AMR between cLADs and iLADs was not due to systematic difference in copy number gain or loss. Copy number log2 ratios were obtained from the cBio portal, and were reported as segment means. Whiskers in the boxplot indicate upper and lower quartiles.
