Two structural studies of the La lupus antigen reveal that the La motif adopts a winged-helix fold at the N terminus and associates with the central RNA-recognition motif to form a binding surface for precursor transcripts synthesized by RNA polymerase III.
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Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila
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Kenan, D., Keene, J. La gets its wings. Nat Struct Mol Biol 11, 303–305 (2004). https://doi.org/10.1038/nsmb0404-303
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DOI: https://doi.org/10.1038/nsmb0404-303
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