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Modifications target spliceosome dynamics

Nature Structural & Molecular Biology volume 15, pages 426–428 (2008)Cite this article

The splicing pathway is dominated by ATP-dependent RNA rearrangements promoted by DEAD-box helicases. Post-translational modifications have now been implicated in the regulation of two DEAD-box proteins that are required for catalytic activation of the spliceosome.

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Figure 1: The steps in spliceosome assembly, catalysis and spliceosome disassembly are shown schematically.
Figure 2: ATP-dependent exchange of RNA pairing partners is mediated by DEAD-box helicases.
Figure 3: Post-translational modifications target spliceosomal dynamics.

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Acknowledgements

We thank T. Kress and R. Holmes for helpful discussions.

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  1. Corina Maeder and Christine Guthrie are in the Department of Biochemistry and Biophysics, Genentech Hall N374, University of California San Francisco, 600 16th Street, San Francisco, California 94143-2200, USA. guthrie@biochem.ucsf.edu.,

    Corina Maeder & Christine Guthrie

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  2. Christine Guthrie
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Maeder, C., Guthrie, C. Modifications target spliceosome dynamics. Nat Struct Mol Biol 15, 426–428 (2008). https://doi.org/10.1038/nsmb0508-426

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