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A helicase staircase

Nature Structural & Molecular Biology volume 13, pages 671–672 (2006)Cite this article

A new crystal structure reveals the path taken by single-stranded (ss) DNA through the central channel of a hexameric helicase. The path resembles a spiral staircase and provides an answer to the question of how hexameric helicases translocate on ssDNA.

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Figure 1: Mechanism for translocation of BPV E1 on ssDNA.

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Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, 72205, Arkansas, USA

    Kevin D Raney

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  1. Kevin D Raney
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Raney, K. A helicase staircase. Nat Struct Mol Biol 13, 671–672 (2006). https://doi.org/10.1038/nsmb0806-671

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