Abstract
The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core.
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Acknowledgements
This work was partly funded by grants from the Office of the Chief Scientist, Health Canada.
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Supplementary information
Supplementary Fig. 1
Purification and immunolabeling of SARS-CoV (PDF 930 kb)
Supplementary Fig. 2
Projection matching of SARS-CoV spikes (PDF 2270 kb)
Supplementary Fig. 3
Angular distribution and estimate of resolution of the SARS-CoV spike (PDF 61 kb)
Supplementary Fig. 4
Domain structure of the SARS-CoV spike and docking atomic structures (PDF 2837 kb)
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Beniac, D., Andonov, A., Grudeski, E. et al. Architecture of the SARS coronavirus prefusion spike. Nat Struct Mol Biol 13, 751–752 (2006). https://doi.org/10.1038/nsmb1123
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DOI: https://doi.org/10.1038/nsmb1123
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