Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Coordinated control of splicing and translation

Nature Structural & Molecular Biology volume 12, pages 1022–1023 (2005)Cite this article

A new study reveals that extracellular signals can activate a signal-transduction cascade that simultaneously alters alternative splicing and translation of the same target. These concerted efforts probably serve to increase the speed and strength of the cellular response to changes in the extracellular environment.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A model connecting signal transduction, alternative splicing and translation regulation.

References

  1. Graveley, B.R. Trends Genet. 17, 100–107 (2001).

    Article  CAS  Google Scholar 

  2. Matlin, A.J., Clark, F. & Smith, C.W. Nat. Rev. Mol. Cell Biol. 6, 386–398 (2005).

    Article  CAS  Google Scholar 

  3. Shin, C. & Manley, J.L. Nat. Rev. Mol. Cell Biol. 5, 727–738 (2004).

    Article  CAS  Google Scholar 

  4. Blaustein et al. Nat. Struct. Mol. Biol. 12, 1037–1044 (2005).

    Article  CAS  Google Scholar 

  5. Graveley, B.R. RNA 6, 1197–1211 (2000).

    Article  CAS  Google Scholar 

  6. Huang, Y., Gattoni, R., Stevenin, J. & Steitz, J.A. Mol. Cell 11, 837–843 (2003).

    Article  CAS  Google Scholar 

  7. Huang, Y. & Steitz, J.A. Mol. Cell 7, 899–905 (2001).

    Article  CAS  Google Scholar 

  8. Lemaire, R. et al. Genes Dev. 16, 594–607 (2002).

    Article  CAS  Google Scholar 

  9. Zhang, Z. & Krainer, A.R. Mol. Cell 16, 597–607 (2004).

    Article  CAS  Google Scholar 

  10. Li, X. & Manley, J.L. Cell 122, 365–378 (2005).

    Article  CAS  Google Scholar 

  11. Sanford, J.R., Gray, N.K., Beckmann, K. & Caceres, J.F. Genes Dev. 18, 755–768 (2004).

    Article  CAS  Google Scholar 

  12. Hertel, K.J. & Graveley, B.R. Trends Biochem. Sci. 30, 115–118 (2005).

    Article  CAS  Google Scholar 

  13. Patel, N.A. et al. J. Biol. Chem. 280, 14302–14309 (2005).

    Article  CAS  Google Scholar 

  14. Heinrich, R., Neel, B.G. & Rapoport, T.A. Mol. Cell 9, 957–970 (2002).

    Article  CAS  Google Scholar 

  15. Maniatis, T. & Reed, R. Nature 416, 499–506 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, 06030-3301, Connecticut, USA

    Brenton R Graveley

Authors
  1. Brenton R Graveley
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graveley, B. Coordinated control of splicing and translation. Nat Struct Mol Biol 12, 1022–1023 (2005). https://doi.org/10.1038/nsmb1205-1022

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nsmb1205-1022

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing