Figure 4

Hypothalamic ARC mRNA expression of inflammatory genes in the JCR:LA-cp obese-prone and lean-prone rats following CR (n=6 rats per group). Data are shown as mean±s.e.m. *P<0.05 Lean-FF compared with Obese-FF; #P<0.05 Obese-FF compared with Obese-FR or Lean-FF vs Lean-FR. FF, free feeding; FR, food restricted; IL-6, interleukin-6; TNFα, tumor necrosis factor-α; NF-κB, nuclear factor-κB. Target gene expression was normalized to a reference gene (cyclophilin).