Table 2 Characteristics of subjects with low and high plasma apoB

From: Plasma IL-1Ra: linking hyperapoB to risk factors for type 2 diabetes independent of obesity in humans

Characteristics

Low plasma apoB (<20 th percentile, N=17)

HyperapoB (>8 0th percentile, N=17)

Plasma apoB (g l−1)

0.66±0.03

1.32±0.04***

(min–max)

0.34–0.78

1.14–1.80

Sex (male:female)

7:10

7:10

Age (years)

56.2±1.1

59.4±1.3

Weight (kg)

91.4±5.3

89.6±4.4

BMI (kg m−2)

33.8±1.2

32.9±1.2

Total fat mass (kg)

38.4±2.8

37.7±2.6

Lean body fat (kg)

49.4±3.1

48.7±2.6

Android fat (kg)

3.98±0.43

4.11±0.34

Gynoid fat (kg)

6.09±0.44

5.69±0.39

Android/gynoid

0.676±0.059

0.744±0.059

Waist circumference (cm)

111±4

108±3

Waist/hip circumference

0.98±0.03

0.97±0.02

Plasma total cholesterol (mmol l−1)

4.42±0.16

6.57±0.23***

Plasma non-HDL cholesterol (mmol l−1)

2.91±0.14

5.33±0.23***

Plasma LDL cholesterol (mmol l−1)

2.39±0.13

4.02±0.16***

Plasma HDL cholesterol (mmol l−1)

1.51±0.15

1.24±0.09

Mean LDL size (A°)

270±1

264±2**

Plasma TG (mmol l−1)

1.14±0.17

2.87±0.49***

Plasma NEFA (mmol l−1)

0.474±0.047

0.498±0.031

Plasma ApoA-I (g l−1)

1.58±0.08

1.59±0.07

Systolic blood pressure (mm Hg)

123±5

127±4

Diastolic blood pressure (mm Hg)

76±3

79±1

Plasma IL-1β (pg ml−1)

0.094±0.004

0.091±0.002

Plasma IL-1Ra (pg ml−1)

269±34

463±113a*

Fasting plasma glucose (mmol l−1)

5.10±0.09

5.36±0.17

HbA1c

0.056±0.001

0.058±0.001b

Fasting plasma insulin (μU ml−1)

19.4±1.8

22.8±2.3

Fasting plasma C-peptide (ng ml−1)

2.15±0.21

2.77±0.22*

Fasting QUICKI

0.312±0.005

0.303±0.004

First-phase insulin secretionIVGTT (μU ml−1)

948±180

1087±136

Second-phase insulin secretionIVGTT (μU ml−1)

2898±375

4052±611

Total insulin secretionIVGTT (μU ml−1)

3646±509

5138±724

Total C-peptide secretionIVGTT (ng ml−1)

291±33

394±38*

Insulin at steady stateclamp (μU ml−1)

255±13

276±21

Glucose infusion rateClamp (mg (kg × min)−1)

12.2±1.0

9.1±1.1*

M/IClamp (mg (kg × min)−1)/(μU ml−1)

0.052±0.007

0.037±0.006*

Disposition index (mg (kg × min)−1)

163±15

159±20

  1. Abbreviations: BMI, body mass index; HbA1C, glycated hemoglobin; HDL, high-density lipoproteins; IL, interleukin; IVGTT, intravenous glucose tolerance test; LDL, low-density lipoproteins; M/I, glucose infusion rate/steady-state plasma insulin; NEFA, non-essential fatty acid; QUICKI, quantitative insulin sensititvity check index; TG, triglycerides. Data are presented as mean±s.e.m. *P⩽0.05 and **P⩽0.01, ***P⩽0.001 for group differences by unpaired t-test. Statistical analysis was conducted on the Log10 of insulin and C-peptide secretions, M/I and IL-1Ra.
  2. aN=16 missing samples.
  3. bN=15 missing samples.
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