Table 2 Metabolites that correlate with the accumulation of fat depots and lean tissue according to the linear regression models

From: NMR-based metabolic profiling in healthy individuals overfed different types of fat: links to changes in liver fat accumulation and lean tissue mass

MRI assessment

Positive correlations

Negative correlation

 

Metabolite

r2

P

Metabolite

r2

P

Lean tissue

Lactate

0.1

0.07

Leucine

0.16

0.02

    

Valine

0.16

0.02

Visceral adipose tissue

Leucine

0.16

0.02

Alanine

0.12

0.04

 

Valine

0.16

0.02

Lactatea

0.06

0.14

Liver fat

3-methyl-2-oxovalerate

0.09

0.09

Alanine

0.08

0.09

Total body fat

3-hydroxybutyratea

0.04

0.25

Alanine

0.18

0.01

 

3-methyl-2-oxovalerate

0.16

0.02

Lactatea

0.06

0.15

 

Acetate

0.11

0.06

   
 

Leucine

0.14

0.03

   
  1. Abbreviations: MRI, magnetic resonance imaging. Inclusion criteria for correlating metabolites; higher P(corr) than 0.5 and a higher variable importance plot (VIP) value than 2 in the OPLS models, together with a P-value lower than 0.1.
  2. aIncluded owing to the high importance when group discrimination was considered.
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