Table 1 The effect of the combination of the ALDH2*2 allele and the GGT level on the risk for NAFLD in a longitudinal multivariable logistic regression analysis

From: The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease

 

OR (95% CI) a

P-value

Combination of the ALDH2 genotype and the GGT level

 *1/*1 genotype with GGT level <25.5 IUl−1

1

—

 *1/*1 genotype with GGT level ⩾25.5 IUl−1

1.53 (0.68–3.45)

0.308

 *1/*2 or *2/*2 genotype with GGT level <25.5 IUl−1

1.92 (0.82–4.50)

0.132

 *1/*2 or *2/*2 genotype with GGT level ⩾25.5 IUl−1

4.28 (1.80–10.19)

0.001

Gender

 Male

1

—

 Female

2.82 (1.47–5.42)

0.002

BMI (kgm−2)

1.49 (1.30–1.71)

<0.001

HDL-C (mgdl−1)

0.96 (0.94–0.99)

0.003

TG (mgdl−1)

1.01 (1.002–1.013)

0.007

Diabetes

 Absent

1

—

 Present

2.61 (1.30–5.22)

0.007

PNPLA3

 C/C genotype

1

—

 C/G or G/G genotype

3.42 (1.59–7.33)

0.002

  1. Abbreviations: ALDH2, aldehyde dehydrogenase 2; BMI, body mass index; CI, confidence interval; GGT, gamma-glutamyl transferase; HDL-C, high-density lipoprotein cholesterol; NAFLD, nonalcoholic fatty liver disease; OR, odds ratio; PNPLA3, patatin-like phospholipase domain-containing 3; TG, triglycerides.
  2. aAdjusted by all covariates.
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