Figure 1 | Nutrition & Diabetes

Figure 1

From: Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia

Figure 1

Amelioration of glucose metabolism by EPA supplementation. (a) Changes in blood glucose levels fed ad libitum. (b) Changes in body weight. (c) Blood glucose levels after oral glucose loading (1 g kg−1). (d) Blood glucose levels after intraperitoneal insulin administration (0.75 U kg−1). (e, f) mRNA expression levels of Pck1 (e) and G6pc (f) in the liver at fasted (after 16 h fasting) and refed (after 3 h refeeding) state. *P<0.05, **P<0.01, ***P<0.001. (g) Changes in blood glucose levels after intraperitoneal glycerol administration (0.5 g kg−1). Data are mean±s.e.m. (a–d, g) ¶P<0.05 (InsrP1195L/+/HFD vs WT/HFD); §P<0.05 (InsrP1195L/+/HFD vs InsrP1195L/+/HFD+EPA); †P<0.05 (WT/HFD vs WT/HFD+EPA); ‡P<0.05 (InsrP1195L/+/HFD+EPA vs WT/HFD+EPA). The number in the parenthesis (a–d, g) and in the bottom of the columns (e, f) denotes sample size.

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