Figure 4
From: Liraglutide reduces body weight by upregulation of adenylate cyclase 3
Expression of the AC3 and GLP-1R mRNAs and proteins in the liver after treatment with liraglutide (L) or saline (S). Expression of the AC3 and GLP-1R mRNAs and proteins in liver tissues of mice treated with liraglutide or saline are shown in (a–d), respectively. The image of AC3 and GLP-1R from western blotting experiments is represented in (e and f). The P-values for the effect of the interaction between obesity and liraglutide treatment on the hepatic AC3 mRNA, GLP-1R mRNA, AC3 protein and GLP-1R protein levels are 0.724, 0.96, 0.846 and 0.005, respectively. Values are presented as means±s.d. (n=8 per group, when detecting the expression levels of the AC3 and GLP-1R mRNAs; n=6 per group, when detecting the expression levels of the AC3 and GLP-1R proteins). *P<0.05, **P<0.01 for the comparison between the saline and liraglutide groups; #P<0.05, ##P<0.01 for the comparison between the normal and obese groups.
